6OUN
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)3TC-TP
Summary for 6OUN
Entry DOI | 10.2210/pdb6oun/pdb |
Descriptor | Reverse transcriptase/ribonuclease H, P51 RT, DNA primer 20-mer, ... (8 entities in total) |
Functional Keywords | reverse transcriptase, ternary complex, (-)3tc-tp, chain terminator, lamivudine, stereochemistry, transferase, transferase-dna complex, transferase/dna |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 4 |
Total formula weight | 132732.66 |
Authors | Bertoletti, N.,Anderson, K.S. (deposition date: 2019-05-04, release date: 2019-07-24, Last modification date: 2023-10-11) |
Primary citation | Bertoletti, N.,Chan, A.H.,Schinazi, R.F.,Yin, Y.W.,Anderson, K.S. Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine. Protein Sci., 28:1664-1675, 2019 Cited by PubMed: 31301259DOI: 10.1002/pro.3681 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.656 Å) |
Structure validation
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