6OUN

Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)3TC-TP

6OUN の概要

• エントリーDOI: 10.2210/pdb6oun/pdb
• 分子名称: Reverse transcriptase/ribonuclease H, P51 RT, DNA primer 20-mer, ... (8 entities in total)
• 機能のキーワード: reverse transcriptase, ternary complex, (-)3tc-tp, chain terminator, lamivudine, stereochemistry, transferase, transferase-dna complex, transferase/dna
• 由来する生物種: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132732.66

構造登録者

Bertoletti, N.,Anderson, K.S. (登録日: 2019-05-04, 公開日: 2019-07-24, 最終更新日: 2023-10-11)

• 主引用文献: Bertoletti, N.,Chan, A.H.,Schinazi, R.F.,Yin, Y.W.,Anderson, K.S.; Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.; Protein Sci., 28:1664-1675, 2019; PubMed: 31301259; DOI: 10.1002/pro.3681

実験手法

X-RAY DIFFRACTION (2.656 Å)