6OQC

Crystal structure of Mcl1 with inhibitor 9

Summary for 6OQC

• Entry DOI: 10.2210/pdb6oqc/pdb
• Related: 6O6F 6O6G 6OQB
• Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, (4S,7aR,9aR,10S,11E,15R)-6'-chloro-10-hydroxy-15-methyl-3',4',7a,8,9,9a,10,13,14,15-decahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1'-naphthalene]-16,16,18(7H,17H)-trione (3 entities in total)
• Functional Keywords: mcl1, apoptosis, protein-protein, inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 37015.00

Authors

Huang, X. (deposition date: 2019-04-26, release date: 2019-05-15, Last modification date: 2024-03-13)

• Primary citation: Huang, X.; AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.; CANCER DISCOV, 8:1582-1597, 2018; PubMed: 30254093; DOI: 10.1158/2159-8290.CD-18-0387

Experimental method

X-RAY DIFFRACTION (1.8 Å)