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6OPX

HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, L76V, V82F, I84V Mutant in complex with darunavir

Summary for 6OPX
Entry DOI10.2210/pdb6opx/pdb
DescriptorProtease NL4-3, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
Functional Keywordshiv, nl4-3 protease, drug resistance, protease inhibitor, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22395.35
Authors
Lockbaum, G.J.,Henes, M.,Kosovrasti, K.,Leidner, F.,Nachum, G.S.,Nalivaika, E.A.,Bolon, D.N.A.,KurtYilmaz, N.,Schiffer, C.A. (deposition date: 2019-04-25, release date: 2019-09-04, Last modification date: 2023-10-11)
Primary citationHenes, M.,Lockbaum, G.J.,Kosovrasti, K.,Leidner, F.,Nachum, G.S.,Nalivaika, E.A.,Lee, S.K.,Spielvogel, E.,Zhou, S.,Swanstrom, R.,Bolon, D.N.A.,Kurt Yilmaz, N.,Schiffer, C.A.
Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Acs Chem.Biol., 14:2441-2452, 2019
Cited by
PubMed: 31361460
DOI: 10.1021/acschembio.9b00370
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.03 Å)
Structure validation

217705

건을2024-03-27부터공개중

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