6OPX
HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, L76V, V82F, I84V Mutant in complex with darunavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Protease NL4-3 | polymer | 99 | 10923.8 | 2 | UniProt (Q7ZCI0) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | C (B) | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) | |||
| 3 | D, E (B, A) | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 99 (UniProt: Q7ZCI0)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Val 13 | Ile 13 | engineered mutation |
| Glu 16 | Gly 16 | engineered mutation |
| Ile 32 | Val 32 | engineered mutation |
| Phe 33 | Leu 33 | engineered mutation |
| Ile 45 | Lys 45 | engineered mutation |
| Ile 46 | Met 46 | engineered mutation |
| Val 76 | Leu 76 | engineered mutation |
| Phe 82 | Val 82 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21847.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 547.7 | |
| All* | Total formula weight | 22395.3 |
