6OPU
HIV-1 Protease NL4-3 K45I, M46I, V82F, I84V Mutant in complex with darunavir
Summary for 6OPU
Entry DOI | 10.2210/pdb6opu/pdb |
Descriptor | Protease NL4-3, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total) |
Functional Keywords | hiv, nl4-3 protease, drug resistance, protease inhibitor, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22211.24 |
Authors | Lockbaum, G.J.,Henes, M.,Kosovrasti, K.,Leidner, F.,Nachum, G.S.,Nalivaika, E.A.,Bolon, D.N.A.,KurtYilmaz, N.,Schiffer, C.A. (deposition date: 2019-04-25, release date: 2019-09-04, Last modification date: 2023-10-11) |
Primary citation | Henes, M.,Lockbaum, G.J.,Kosovrasti, K.,Leidner, F.,Nachum, G.S.,Nalivaika, E.A.,Lee, S.K.,Spielvogel, E.,Zhou, S.,Swanstrom, R.,Bolon, D.N.A.,Kurt Yilmaz, N.,Schiffer, C.A. Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance. Acs Chem.Biol., 14:2441-2452, 2019 Cited by PubMed: 31361460DOI: 10.1021/acschembio.9b00370 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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