6OO9

Human CYP3A4 bound to a drug mibefradil

Summary for 6OO9

Entry DOI	10.2210/pdb6oo9/pdb
Descriptor	Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, (1S,2S)-2-(2-{[3-(1H-benzimidazol-2-yl)propyl](methyl)amino}ethyl)-6-fluoro-1-(propan-2-yl)-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate, ... (6 entities in total)
Functional Keywords	substrate, complex, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	57072.20
Authors	Sevrioukova, I.F. (deposition date: 2019-04-22, release date: 2019-09-11, Last modification date: 2023-10-11)
Primary citation	Sevrioukova, I.F. Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, Azamulin and 6',7'-Dihydroxybergamottin. Int J Mol Sci, 20:-, 2019 Cited by PubMed: 31480231 DOI: 10.3390/ijms20174245 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation