6OL2
Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening
Summary for 6OL2
Entry DOI | 10.2210/pdb6ol2/pdb |
Descriptor | Serine/threonine-protein kinase WNK1, N-[2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]-2-iodobenzamide, GLYCEROL, ... (5 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (Rat) |
Total number of polymer chains | 1 |
Total formula weight | 34505.28 |
Authors | Chlebowicz, J.,Akella, R.,Sekulski, K.,Humphreys, J.M.,Durbacz, M.Z.,He, H.,Rodan, A.,Posner, B.,Goldsmith, E.J. (deposition date: 2019-04-15, release date: 2020-04-15, Last modification date: 2023-10-11) |
Primary citation | Chlebowicz, J.,Akella, R.,Sekulski, K.,Humphreys, J.M.,Durbacz, M.Z.,He, H.,Rodan, A.,Posner, B.,Goldsmith, E.J. Crystallography of novel WNK1 and WNK3 inhibitors discovered from high throughput screening To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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