6OI8

Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with 7-((1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)-6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine

Summary for 6OI8

Entry DOI	10.2210/pdb6oi8/pdb
Related	4MV1 4MV3 4MV4 4MV6 4MV7 4MV8 4MV9 4RZQ
Descriptor	Biotin carboxylase, 1,2-ETHANEDIOL, 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine, ... (4 entities in total)
Functional Keywords	atp grasp, carboxylase, inhibitor, ligase
Biological source	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Total number of polymer chains	1
Total formula weight	51838.53
Authors	Andrews, L.D.,Kane, T.R.,Dozzo, P.,Haglund, C.M.,Hilderbrandt, D.J.,Linsell, M.S.,Machajewski, T.,McEnroe, G.,Serio, A.W.,Wlasichuk, K.B.,Neau, D.B.,Pakhomova, S.,Waldrop, G.L.,Sharp, M.,Pogliano, J.,Cirz, R.,Cohen, F. (deposition date: 2019-04-09, release date: 2019-07-31, Last modification date: 2023-10-11)
Primary citation	Andrews, L.D.,Kane, T.R.,Dozzo, P.,Haglund, C.M.,Hilderbrandt, D.J.,Linsell, M.S.,Machajewski, T.,McEnroe, G.,Serio, A.W.,Wlasichuk, K.B.,Neau, D.B.,Pakhomova, S.,Waldrop, G.L.,Sharp, M.,Pogliano, J.,Cirz, R.T.,Cohen, F. Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase. J.Med.Chem., 62:7489-7505, 2019 Cited by PubMed: 31306011 DOI: 10.1021/acs.jmedchem.9b00625 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation