6OI8

Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with 7-((1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)-6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine

6OI8 の概要

• エントリーDOI: 10.2210/pdb6oi8/pdb
• 関連するPDBエントリー: 4MV1 4MV3 4MV4 4MV6 4MV7 4MV8 4MV9 4RZQ
• 分子名称: Biotin carboxylase, 1,2-ETHANEDIOL, 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine, ... (4 entities in total)
• 機能のキーワード: atp grasp, carboxylase, inhibitor, ligase
• 由来する生物種: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51838.53

構造登録者

Andrews, L.D.,Kane, T.R.,Dozzo, P.,Haglund, C.M.,Hilderbrandt, D.J.,Linsell, M.S.,Machajewski, T.,McEnroe, G.,Serio, A.W.,Wlasichuk, K.B.,Neau, D.B.,Pakhomova, S.,Waldrop, G.L.,Sharp, M.,Pogliano, J.,Cirz, R.,Cohen, F. (登録日: 2019-04-09, 公開日: 2019-07-31, 最終更新日: 2023-10-11)

• 主引用文献: Andrews, L.D.,Kane, T.R.,Dozzo, P.,Haglund, C.M.,Hilderbrandt, D.J.,Linsell, M.S.,Machajewski, T.,McEnroe, G.,Serio, A.W.,Wlasichuk, K.B.,Neau, D.B.,Pakhomova, S.,Waldrop, G.L.,Sharp, M.,Pogliano, J.,Cirz, R.T.,Cohen, F.; Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.; J.Med.Chem., 62:7489-7505, 2019; PubMed: 31306011; DOI: 10.1021/acs.jmedchem.9b00625

実験手法

X-RAY DIFFRACTION (2.5 Å)