6OI2

Crystal structure of human WDR5 in complex with symmetric dimethyl-L-arginine

6OI2 の概要

• エントリーDOI: 10.2210/pdb6oi2/pdb
• 分子名称: WD repeat-containing protein 5, SULFATE ION, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: methylation, epigenetics, post-translational modification, chromatin, methylarginine, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35157.72

構造登録者

Lorton, B.M.,Harijan, R.K.,Burgos, E.,Bonanno, J.B.,Almo, S.C.,Shechter, D. (登録日: 2019-04-08, 公開日: 2020-04-01, 最終更新日: 2023-10-11)

• 主引用文献: Lorton, B.M.,Harijan, R.K.,Burgos, E.S.,Bonanno, J.B.,Almo, S.C.,Shechter, D.; A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5.; Biochemistry, 59:3696-3708, 2020; PubMed: 32207970; DOI: 10.1021/acs.biochem.0c00035

実験手法

X-RAY DIFFRACTION (1.68 Å)