6OHU

Structure of EBP and tamoxifen

Summary for 6OHU

Descriptor3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, (Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE (2 entities in total)
Functional Keywordsmembrane protein, isomerase, isomerase-inhibitor complex, isomerase/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight83380.16
Authors
Long, T.,Li, X. (deposition date: 2019-04-06, release date: 2019-06-19)
Primary citation
Long, T.,Hassan, A.,Thompson, B.M.,McDonald, J.G.,Wang, J.,Li, X.
Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition.
Nat Commun, 10:2452-2452, 2019
PubMed: 31165728 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-019-10279-w
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.526 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.32616 0.2% 5.9% 2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution