6OHR

Structure of compound 5 bound human Phospholipase D1 catalytic domain

Summary for 6OHR

Entry DOI	10.2210/pdb6ohr/pdb
Descriptor	Phospholipase D1, chimeric constuct, 4-fluoro-N-{(2S)-1-[(5R)-5-(3-fluorophenyl)-2-oxo-1-oxa-3,9-diazaspiro[5.5]undecan-9-yl]propan-2-yl}benzamide (2 entities in total)
Functional Keywords	phosphodiesterase, hydrolase, hkd motif, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	446588.03
Authors	Metrick, C.M.,Chodaparambil, J.V. (deposition date: 2019-04-06, release date: 2020-02-19, Last modification date: 2023-10-11)
Primary citation	Metrick, C.M.,Peterson, E.A.,Santoro, J.C.,Enyedy, I.J.,Murugan, P.,Chen, T.,Michelsen, K.,Cullivan, M.,Spilker, K.A.,Kumar, P.R.,May-Dracka, T.L.,Chodaparambil, J.V. Human PLD structures enable drug design and characterization of isoenzyme selectivity. Nat.Chem.Biol., 16:391-399, 2020 Cited by PubMed: 32042197 DOI: 10.1038/s41589-019-0458-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation