6OGN
Crystal structure of mouse protein arginine methyltransferase 7 in complex with SGC8158 chemical probe
Replaces: 6NPGSummary for 6OGN
Entry DOI | 10.2210/pdb6ogn/pdb |
Descriptor | Protein arginine N-methyltransferase 7, ZINC ION, 5'-S-(4-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}butyl)-5'-thioadenosine, ... (5 entities in total) |
Functional Keywords | prmt7, sgc8158, chemical probe, structural genomics, structural genomics consortium, transferase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 80952.60 |
Authors | Halabelian, L.,Dong, A.,Zeng, H.,Li, Y.,Hutchinson, A.,Seitova, A.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC) (deposition date: 2019-04-03, release date: 2019-04-17, Last modification date: 2023-10-11) |
Primary citation | Szewczyk, M.M.,Ishikawa, Y.,Organ, S.,Sakai, N.,Li, F.,Halabelian, L.,Ackloo, S.,Couzens, A.L.,Eram, M.,Dilworth, D.,Fukushi, H.,Harding, R.,Dela Sena, C.C.,Sugo, T.,Hayashi, K.,McLeod, D.,Zepeda, C.,Aman, A.,Sanchez-Osuna, M.,Bonneil, E.,Takagi, S.,Al-Awar, R.,Tyers, M.,Richard, S.,Takizawa, M.,Gingras, A.C.,Arrowsmith, C.H.,Vedadi, M.,Brown, P.J.,Nara, H.,Barsyte-Lovejoy, D. Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nat Commun, 11:2396-2396, 2020 Cited by PubMed: 32409666DOI: 10.1038/s41467-020-16271-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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