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6OGN

Crystal structure of mouse protein arginine methyltransferase 7 in complex with SGC8158 chemical probe

Replaces:  6NPG
Functional Information from GO Data
ChainGOidnamespacecontents
A0000387biological_processspliceosomal snRNP assembly
A0001650cellular_componentfibrillar center
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0006479biological_processprotein methylation
A0008168molecular_functionmethyltransferase activity
A0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
A0016274molecular_functionprotein-arginine N-methyltransferase activity
A0018216biological_processpeptidyl-arginine methylation
A0030154biological_processcell differentiation
A0032259biological_processmethylation
A0035241molecular_functionprotein-arginine omega-N monomethyltransferase activity
A0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
A0042054molecular_functionhistone methyltransferase activity
A0042393molecular_functionhistone binding
A0043021molecular_functionribonucleoprotein complex binding
A0044020molecular_functionhistone H4R3 methyltransferase activity
A0071514biological_processgenomic imprinting
A0140939molecular_functionhistone H4 methyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 701
ChainResidue
ACYS219
ACYS366
ACYS368
AHIS371

site_idAC2
Number of Residues13
Detailsbinding site for residue MJ7 A 702
ChainResidue
AHIS122
ASER123
ALEU145
APHE146
ASER158
AILE284
AMET286
ACYS294
ATYR35
AGLY72
AGLU94
AVAL95
ALYS121

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
AGLU144
AGLU153

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315
ChainResidueDetails
AARG32

222624

PDB entries from 2024-07-17

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