6OFY

Crystal Structure of Arachidonic Acid bound to V349I murine COX-2

6OFY の概要

• エントリーDOI: 10.2210/pdb6ofy/pdb
• 分子名称: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING CO, ... (7 entities in total)
• 機能のキーワード: arachidonic acid cyclooxygenase prostaglandin endoperoxide synthase, membrane protein, oxidoreductase
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 131207.35

構造登録者

Malkowski, M.G. (登録日: 2019-04-01, 公開日: 2020-02-05, 最終更新日: 2023-10-11)

• 主引用文献: Dong, L.,Anderson, A.J.,Malkowski, M.G.; Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex.; Biochemistry, 58:3990-4002, 2019; PubMed: 31469551; DOI: 10.1021/acs.biochem.9b00659

実験手法

X-RAY DIFFRACTION (2.2 Å)