6OFC
Crystal structure of M. tuberculosis glutamine-dependent NAD+ synthetase complexed with Sulfonamide derivative 1, pyrophosphate, and glutamine
Summary for 6OFC
Entry DOI | 10.2210/pdb6ofc/pdb |
Related | 6OFB |
Descriptor | Glutamine-dependent NAD(+) synthetase, 5'-O-[(pyridine-3-carbonyl)sulfamoyl]adenosine, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | ligase, glutamine-amido transferase, gat, nad+ synthetase, glutamine-dependent nad+ synthetase, nad synthetase 1, glutaminase, ammonia tunneling, enzyme, atp-binding, nucleotide-binding, inhibitor complex, tuberculosis |
Biological source | Mycobacterium tuberculosis CDC1551 |
Total number of polymer chains | 4 |
Total formula weight | 303496.79 |
Authors | Chuenchor, W.,Doukov, T.I.,Gerratana, B. (deposition date: 2019-03-28, release date: 2020-01-08, Last modification date: 2023-10-25) |
Primary citation | Chuenchor, W.,Doukov, T.I.,Chang, K.T.,Resto, M.,Yun, C.S.,Gerratana, B. Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD+synthetases. Nat Commun, 11:16-16, 2020 Cited by PubMed: 31911602DOI: 10.1038/s41467-019-13845-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.14 Å) |
Structure validation
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