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6OFC

Crystal structure of M. tuberculosis glutamine-dependent NAD+ synthetase complexed with Sulfonamide derivative 1, pyrophosphate, and glutamine

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003952molecular_functionNAD+ synthase (glutamine-hydrolyzing) activity
A0004359molecular_functionglutaminase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0008795molecular_functionNAD+ synthase activity
A0009274cellular_componentpeptidoglycan-based cell wall
A0009435biological_processNAD+ biosynthetic process
A0016874molecular_functionligase activity
A0042802molecular_functionidentical protein binding
B0000166molecular_functionnucleotide binding
B0003952molecular_functionNAD+ synthase (glutamine-hydrolyzing) activity
B0004359molecular_functionglutaminase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0008795molecular_functionNAD+ synthase activity
B0009274cellular_componentpeptidoglycan-based cell wall
B0009435biological_processNAD+ biosynthetic process
B0016874molecular_functionligase activity
B0042802molecular_functionidentical protein binding
C0000166molecular_functionnucleotide binding
C0003952molecular_functionNAD+ synthase (glutamine-hydrolyzing) activity
C0004359molecular_functionglutaminase activity
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0008795molecular_functionNAD+ synthase activity
C0009274cellular_componentpeptidoglycan-based cell wall
C0009435biological_processNAD+ biosynthetic process
C0016874molecular_functionligase activity
C0042802molecular_functionidentical protein binding
D0000166molecular_functionnucleotide binding
D0003952molecular_functionNAD+ synthase (glutamine-hydrolyzing) activity
D0004359molecular_functionglutaminase activity
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0008795molecular_functionNAD+ synthase activity
D0009274cellular_componentpeptidoglycan-based cell wall
D0009435biological_processNAD+ biosynthetic process
D0016874molecular_functionligase activity
D0042802molecular_functionidentical protein binding
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue SFH A 701
ChainResidue
AGLY366
ATRP490
ASER491
ATHR492
AASP497
AHOH803
AVAL367
ASER368
ASER373
APHE397
AALA398
ALEU399
AARG462
ATHR480

site_idAC2
Number of Residues11
Detailsbinding site for residue SFH A 702
ChainResidue
AASN456
ATHR492
ATYR493
APHE634
ALYS635
ASER661
DARG354
DLEU358
DASN471
DGLY475
DHIS501

site_idAC3
Number of Residues17
Detailsbinding site for residue SFH A 703
ChainResidue
AARG354
ALEU358
AASN471
AGLY475
AILE476
AHIS501
DASN456
DGLY489
DSER491
DTHR492
DTYR493
DARG627
DPHE631
DPHE634
DLYS635
DSER661
DSFH701

site_idAC4
Number of Residues1
Detailsbinding site for residue CL A 705
ChainResidue
AMET663

site_idAC5
Number of Residues16
Detailsbinding site for residue SFH B 701
ChainResidue
BGLY366
BVAL367
BSER368
BSER373
BPHE397
BALA398
BLEU399
BARG462
BTHR480
BTRP490
BSER491
BTHR492
BASP497
BGLU552
BPOP705
BHOH806

site_idAC6
Number of Residues13
Detailsbinding site for residue SFH B 702
ChainResidue
BASN456
BTHR492
BTYR493
BPHE631
BPHE634
BLYS635
BSER661
BHOH807
CARG354
CLEU358
CASN471
CGLY475
CHIS501

site_idAC7
Number of Residues10
Detailsbinding site for residue SFH B 703
ChainResidue
BARG354
BLEU358
BASN471
BGLY475
BILE476
BHIS501
CASN456
CTYR493
CPHE634
CLYS635

site_idAC8
Number of Residues1
Detailsbinding site for residue CL B 704
ChainResidue
BMET499

site_idAC9
Number of Residues10
Detailsbinding site for residue POP B 705
ChainResidue
BSER368
BGLY370
BLEU371
BASP372
BSER373
BGLU541
BGLU552
BGLU553
BLEU554
BSFH701

site_idAD1
Number of Residues3
Detailsbinding site for residue GLN B 706
ChainResidue
BARG218
DLEU215
DARG218

site_idAD2
Number of Residues6
Detailsbinding site for residue GOL B 707
ChainResidue
AASP656
BASP62
BARG134
AARG128
AARG285
ALEU575

site_idAD3
Number of Residues13
Detailsbinding site for residue SFH C 701
ChainResidue
CGLY366
CVAL367
CSER368
CSER373
CPHE397
CALA398
CLEU399
CARG462
CTHR480
CTRP490
CSER491
CTHR492
CASP497

site_idAD4
Number of Residues12
Detailsbinding site for residue GLN C 702
ChainResidue
CGLU52
CTYR58
CLYS121
CPRO125
CTYR127
CPHE130
CALA176
CGLU177
CPHE180
CSER203
CARG209
CHOH801

site_idAD5
Number of Residues10
Detailsbinding site for residue SFH D 701
ChainResidue
ASFH703
DGLY366
DVAL367
DSER368
DPHE397
DLEU399
DARG462
DTHR480
DTRP490
DTHR492

site_idAD6
Number of Residues3
Detailsbinding site for residue CL D 702
ChainResidue
DTHR463
DASP497
DMET499

site_idAD7
Number of Residues5
Detailsbinding site for residue GLN D 703
ChainResidue
DTYR127
DGLU177
DPHE180
DSER203
DARG209

site_idAD8
Number of Residues6
Detailsbinding site for residue GOL D 704
ChainResidue
ALEU65
AARG134
BARG128
DARG285
DLEU575
DASP656

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1056
DetailsDomain: {"description":"CN hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00054","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues76
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsActive site: {"description":"Proton acceptor; for glutaminase activity","evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15748981","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19270703","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsActive site: {"description":"For glutaminase activity","evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15748981","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19270703","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsActive site: {"description":"Nucleophile; for glutaminase activity","evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15748981","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19270703","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3SYT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3SEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SYT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues4
DetailsBinding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3DLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3SEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SYT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues4
DetailsBinding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3SEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SYT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues16
DetailsBinding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3DLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SYT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PDB","id":"3DLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SYT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues4
DetailsBinding site: {"description":"in other chain","evidences":[{"source":"PDB","id":"3DLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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