6OF1

Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution

This is a non-PDB format compatible entry.

Summary for 6OF1

• Entry DOI: 10.2210/pdb6of1/pdb
• Descriptor: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total)
• Functional Keywords: dirithromycin, macrolide, antibiotic, 70s ribosome, inhibitor, nascent peptide exit tunnel, ribosomal protein ul4, ribosome
• Biological source: Escherichia coli; More
• Total number of polymer chains: 112
• Total formula weight: 4573555.65

Authors

Khabibullina, N.F.,Tereshchenkov, A.G.,Komarova, E.S.,Syroegin, E.A.,Shiriaev, D.I.,Paleskava, A.,Kartsev, V.G.,Bogdanov, A.A.,Konevega, A.L.,Dontsova, O.A.,Sergiev, P.V.,Osterman, I.A.,Polikanov, Y.S. (deposition date: 2019-03-28, release date: 2019-04-17, Last modification date: 2023-11-15)

• Primary citation: Khabibullina, N.F.,Tereshchenkov, A.G.,Komarova, E.S.,Syroegin, E.A.,Shiriaev, D.I.,Paleskava, A.,Kartsev, V.G.,Bogdanov, A.A.,Konevega, A.L.,Dontsova, O.A.,Sergiev, P.V.,Osterman, I.A.,Polikanov, Y.S.; Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides.; Antimicrob.Agents Chemother., 63:-, 2019; PubMed: 30936109; DOI: 10.1128/AAC.02266-18

Experimental method

X-RAY DIFFRACTION (2.8 Å)