6OE7

Crystal structure of HMCES cross-linked to DNA abasic site

Summary for 6OE7

• Entry DOI: 10.2210/pdb6oe7/pdb
• Descriptor: Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, DNA (5'-D(*GP*TP*CP*TP*GP*G)-3'), DNA (5'-D(*CP*CP*AP*GP*AP*CP*GP*TP*(DRZ)P*GP*TP*T)-3'), ... (6 entities in total)
• Functional Keywords: srap domain, dna-binding, structural genomics, structural genomics consortium, sgc, hmces, protein-dna complex, dna damage protein, 3' overhang, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 37367.48

Authors

Halabelian, L.,Li, Y.,Zeng, H.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC) (deposition date: 2019-03-27, release date: 2019-04-24, Last modification date: 2019-07-17)

• Primary citation: Halabelian, L.,Ravichandran, M.,Li, Y.,Zeng, H.,Rao, A.,Aravind, L.,Arrowsmith, C.H.; Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.; Nat.Struct.Mol.Biol., 26:607-612, 2019; PubMed: 31235913; DOI: 10.1038/s41594-019-0246-6

Experimental method

X-RAY DIFFRACTION (2.2 Å)