6OE7

Crystal structure of HMCES cross-linked to DNA abasic site

6OE7 の概要

• エントリーDOI: 10.2210/pdb6oe7/pdb
• 分子名称: Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, DNA (5'-D(*GP*TP*CP*TP*GP*G)-3'), DNA (5'-D(*CP*CP*AP*GP*AP*CP*GP*TP*(DRZ)P*GP*TP*T)-3'), ... (6 entities in total)
• 機能のキーワード: srap domain, dna-binding, structural genomics, structural genomics consortium, sgc, hmces, protein-dna complex, dna damage protein, 3' overhang, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 37367.48

構造登録者

Halabelian, L.,Li, Y.,Zeng, H.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC) (登録日: 2019-03-27, 公開日: 2019-04-24, 最終更新日: 2019-07-17)

• 主引用文献: Halabelian, L.,Ravichandran, M.,Li, Y.,Zeng, H.,Rao, A.,Aravind, L.,Arrowsmith, C.H.; Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.; Nat.Struct.Mol.Biol., 26:607-612, 2019; PubMed: 31235913; DOI: 10.1038/s41594-019-0246-6

実験手法

X-RAY DIFFRACTION (2.2 Å)