6ODE

Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based Inhibitor B6

6ODE の概要

• エントリーDOI: 10.2210/pdb6ode/pdb
• 分子名称: Proteasome subunit alpha, Proteasome subunit beta, N-{(2S)-1-({(1S)-1-[5-(2-fluorophenyl)-1H-imidazol-2-yl]ethyl}amino)-1,4-dioxo-4-[(2R)-2-phenylpyrrolidin-1-yl]butan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide, ... (4 entities in total)
• 機能のキーワード: mycobacterium tuberculosis, proteasome inhibitor, phenylimidazole, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); 詳細
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 713663.45

構造登録者

Hsu, H.C.,Li, H. (登録日: 2019-03-26, 公開日: 2019-10-09, 最終更新日: 2023-10-11)

• 主引用文献: Zhan, W.,Hsu, H.C.,Morgan, T.,Ouellette, T.,Burns-Huang, K.,Hara, R.,Wright, A.G.,Imaeda, T.,Okamoto, R.,Sato, K.,Michino, M.,Ramjee, M.,Aso, K.,Meinke, P.T.,Foley, M.,Nathan, C.F.,Li, H.,Lin, G.; Selective Phenylimidazole-Based Inhibitors of theMycobacterium tuberculosisProteasome.; J.Med.Chem., 62:9246-9253, 2019; PubMed: 31560200; DOI: 10.1021/acs.jmedchem.9b01187

実験手法

X-RAY DIFFRACTION (2.9 Å)