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6OAK

Structure of human PARG complexed with JA2131

Summary for 6OAK
Entry DOI10.2210/pdb6oak/pdb
Related6O9X 6O9Y 6OA0 6OA1 6OA3
DescriptorPoly(ADP-ribose) glycohydrolase, (8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one (3 entities in total)
Functional Keywordshydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight61567.20
Authors
Brosey, C.A.,Ahmed, Z.,Warden, S.,Tainer, J.A. (deposition date: 2019-03-16, release date: 2020-03-18, Last modification date: 2023-10-11)
Primary citationHoul, J.H.,Ye, Z.,Brosey, C.A.,Balapiti-Modarage, L.P.F.,Namjoshi, S.,Bacolla, A.,Laverty, D.,Walker, B.L.,Pourfarjam, Y.,Warden, L.S.,Babu Chinnam, N.,Moiani, D.,Stegeman, R.A.,Chen, M.K.,Hung, M.C.,Nagel, Z.D.,Ellenberger, T.,Kim, I.K.,Jones, D.E.,Ahmed, Z.,Tainer, J.A.
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10:5654-5654, 2019
Cited by
PubMed: 31827085
DOI: 10.1038/s41467-019-13508-4
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

217705

数据于2024-03-27公开中

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