6O97
Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution
This is a non-PDB format compatible entry.
Summary for 6O97
Entry DOI | 10.2210/pdb6o97/pdb |
Descriptor | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total) |
Functional Keywords | propylamycin, aminoglycosides, antibiotic, 70s ribosome, inhibition of translation, decoding center, ribosome-antibiotic complex, ribosome/antibiotic |
Biological source | Escherichia coli More |
Total number of polymer chains | 112 |
Total formula weight | 4575023.39 |
Authors | Matsushita, T.,Sati, G.C.,Kondasinghe, N.,Pirrone, M.G.,Kato, T.,Waduge, P.,Kumar, H.S.,Sanchon, A.C.,Dobosz-Bartoszek, M.,Shcherbakov, D.,Juhas, M.,Hobbie, S.N.,Schrepfer, T.,Chow, C.S.,Polikanov, Y.S.,Schacht, J.,Vasella, A.,Bottger, E.C.,Crich, D. (deposition date: 2019-03-13, release date: 2019-04-17, Last modification date: 2023-11-15) |
Primary citation | Matsushita, T.,Sati, G.C.,Kondasinghe, N.,Pirrone, M.G.,Kato, T.,Waduge, P.,Kumar, H.S.,Sanchon, A.C.,Dobosz-Bartoszek, M.,Shcherbakov, D.,Juhas, M.,Hobbie, S.N.,Schrepfer, T.,Chow, C.S.,Polikanov, Y.S.,Schacht, J.,Vasella, A.,Bottger, E.C.,Crich, D. Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens. J. Am. Chem. Soc., 141:5051-5061, 2019 Cited by PubMed: 30793894DOI: 10.1021/jacs.9b01693 PDB entries with the same primary citation |
Experimental method |
Structure validation
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