6O8D

Anti-CD28xCD3 CODV Fab bound to CD28

Summary for 6O8D

• Entry DOI: 10.2210/pdb6o8d/pdb
• Related: 6O8D
• Descriptor: T-cell-specific surface glycoprotein CD28, Anti-CD28xCD3 CODV Fab Light chain, Anti-CD28xCD3 CODV Fab Heavy chain, ... (5 entities in total)
• Functional Keywords: multispecific antibody, cross-over dual variable immunoglobin, multifunctional biotherapeutic format, bispecific property, codv, immune system, t cell activation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 91250.78

Authors

Lord, D.M.,Wei, R.R. (deposition date: 2019-03-09, release date: 2019-11-20, Last modification date: 2023-10-11)

• Primary citation: Wu, L.,Seung, E.,Xu, L.,Rao, E.,Lord, D.M.,Wei, R.R.,Cortez-Retamozo, V.,Ospina, B.,Posternak, V.,Ulinski, G.,Piepenhagen, P.,Francesconi, E.,El Murr, N.,Beil, C.,Dabdoubi, T.,Cameron, B.,Bertrand, T.,Ferrari, P.,Pouzieux, S.,Lemoine, C.,Prades, C.,Park, A.,Qiu, H.,Song, Z.,Zhang, B.,Sun, F.,Chiron, M.,Rao, S.,Radosevic, K.,Zhi-yong, Y.,Nabel, G.J.; Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation; To Be Published, ; DOI: 10.1038/s43018-019-0004-z

Experimental method

X-RAY DIFFRACTION (3.547 Å)