6O8C

Crystal structure of STING CTT in complex with TBK1

6O8C の概要

分子名称Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide (3 entities in total)
機能のキーワードadaptor, kinase, complex, immune system
由来する生物種Mus musculus (Mouse)
詳細
ポリマー鎖数4
分子量合計162328.6
構造登録者
Li, P.,Zhao, B.,Du, F. (登録日: 2019-03-09, 公開日: 2019-05-22, 最終更新日: 2019-06-12)
主引用文献
Zhao, B.,Du, F.,Xu, P.,Shu, C.,Sankaran, B.,Bell, S.L.,Liu, M.,Lei, Y.,Gao, X.,Fu, X.,Zhu, F.,Liu, Y.,Laganowsky, A.,Zheng, X.,Ji, J.Y.,West, A.P.,Watson, R.O.,Li, P.
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569:718-722, 2019
PubMed: 31118511 (主引用文献が同じPDBエントリー)
DOI: 10.1038/s41586-019-1228-x
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (3.17 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2319 0.9% 11.8% 3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード