6O6E

Crystal structure of PltF trapped with PltL using a proline adenosine vinylsulfonamide inhibitor

Summary for 6O6E

Entry DOI	10.2210/pdb6o6e/pdb
Descriptor	L-proline--[L-prolyl-carrier protein] ligase, Peptidyl carrier protein PltL, FORMIC ACID, ... (7 entities in total)
Functional Keywords	nonribosomal peptide synthetase, nrps, type ii, biosynthesis, pyoluteorin, ligase-transport protein complex, ligase/transport protein
Biological source	Pseudomonas protegens Pf-5 More
Total number of polymer chains	2
Total formula weight	69233.81
Authors	Corpuz, J.C.,Podust, L.M. (deposition date: 2019-03-06, release date: 2020-04-08, Last modification date: 2024-10-23)
Primary citation	Corpuz, J.C.,Podust, L.M.,Davis, T.D.,Jaremko, M.J.,Burkart, M.D. Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis. Rsc Chem Biol, 1:8-12, 2020 Cited by PubMed Abstract: Using a covalent chemical probe and X-ray crystallography coupled to nuclear magnetic resonance data, we elucidated the dynamic molecular basis of protein recognition between the carrier protein and adenylation domain in pyoluteorin biosynthesis. These findings reveal a unique binding mode, which contrasts previously solved carrier protein and partner protein interfaces. PubMed: 33305272 DOI: 10.1039/c9cb00015a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation