6O5T
Crystal Structure of VIM-2 with Compound 16
Summary for 6O5T
| Entry DOI | 10.2210/pdb6o5t/pdb |
| Descriptor | Beta-lactamase class B VIM-2, ZINC ION, [(5,7-dibromo-2-oxo-1,2-dihydroquinolin-4-yl)methyl]phosphonic acid, ... (5 entities in total) |
| Functional Keywords | carbapenemase, phosphonate, inhibitor, complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
| Biological source | Pseudomonas aeruginosa |
| Total number of polymer chains | 2 |
| Total formula weight | 53117.47 |
| Authors | Akhtar, A.,Chen, Y. (deposition date: 2019-03-04, release date: 2019-09-25, Last modification date: 2023-10-11) |
| Primary citation | Pemberton, O.A.,Jaishankar, P.,Akhtar, A.,Adams, J.L.,Shaw, L.N.,Renslo, A.R.,Chen, Y. Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. J.Med.Chem., 62:8480-8496, 2019 Cited by PubMed: 31483651DOI: 10.1021/acs.jmedchem.9b00728 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report
