6O4U

Co-crystal structure of Mcl1 with inhibitor

6O4U の概要

• エントリーDOI: 10.2210/pdb6o4u/pdb
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, (2~{S})-4-(cyclobutylmethyl)-2-(2,4-dichlorophenyl)-~{N}-(2-methylpropylsulfonyl)-2,3-dihydro-1,4-benzoxazine-6-carboxamide (3 entities in total)
• 機能のキーワード: inhibitor, apoptosis, apoptosis-inhibitor complex, apoptosis/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36609.38

構造登録者

Huang, X. (登録日: 2019-03-01, 公開日: 2020-03-04, 最終更新日: 2024-03-13)

• 主引用文献: Huang, X.; Conformational Restriction Toward the Discovery of Macrocyclic MCL1 Inhibitors that Display Efficacy in Mouse Xenograft Models; To Be Published,

実験手法

X-RAY DIFFRACTION (1.7 Å)