6O4I
Structure of ALDH7A1 mutant E399D complexed with alpha-aminoadipate
Summary for 6O4I
Entry DOI | 10.2210/pdb6o4i/pdb |
Descriptor | Alpha-aminoadipic semialdehyde dehydrogenase, 2-AMINOHEXANEDIOIC ACID, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | aldehyde dehydrogenase, nad, oxidoreductase, lysine catabolism |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 447133.06 |
Authors | Tanner, J.J.,Korasick, D.A.,Laciak, A.R. (deposition date: 2019-02-28, release date: 2019-11-06, Last modification date: 2023-11-15) |
Primary citation | Laciak, A.R.,Korasick, D.A.,Gates, K.S.,Tanner, J.J. Structural analysis of pathogenic mutations targeting Glu427 of ALDH7A1, the hot spot residue of pyridoxine-dependent epilepsy. J. Inherit. Metab. Dis., 43:635-644, 2020 Cited by PubMed: 31652343DOI: 10.1002/jimd.12184 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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