6O4H

Structure of ALDH7A1 mutant A171V complexed with NAD

Summary for 6O4H

Entry DOI	10.2210/pdb6o4h/pdb
Descriptor	Alpha-aminoadipic semialdehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	aldehyde dehydrogenase, nad, oxidoreductase, lysine catabolism
Biological source	Homo sapiens (Human)
Total number of polymer chains	8
Total formula weight	450618.88
Authors	Tanner, J.J.,Korasick, D.A.,Laciak, A.R. (deposition date: 2019-02-28, release date: 2019-07-24, Last modification date: 2023-10-11)
Primary citation	Laciak, A.R.,Korasick, D.A.,Wyatt, J.W.,Gates, K.S.,Tanner, J.J. Structural and biochemical consequences of pyridoxine-dependent epilepsy mutations that target the aldehyde binding site of aldehyde dehydrogenase ALDH7A1. Febs J., 287:173-189, 2020 Cited by PubMed: 31302938 DOI: 10.1111/febs.14997 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation