6O47

human cGAS core domain (K427E/K428E) bound with RU-521

Summary for 6O47

Entry DOI	10.2210/pdb6o47/pdb
Descriptor	Cyclic GMP-AMP synthase, CITRIC ACID, ZINC ION, ... (6 entities in total)
Functional Keywords	human, cgas, core domain, compound, ru-521, dna binding protein, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	44766.16
Authors	Xie, W.,Lama, L.,Adura, C.,Glickman, J.F.,Tuschl, T.,Patel, D.J. (deposition date: 2019-02-28, release date: 2019-05-29, Last modification date: 2023-10-11)
Primary citation	Xie, W.,Lama, L.,Adura, C.,Tomita, D.,Glickman, J.F.,Tuschl, T.,Patel, D.J. Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Proc.Natl.Acad.Sci.USA, 116:11946-11955, 2019 Cited by PubMed: 31142647 DOI: 10.1073/pnas.1905013116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.196 Å)

Structure validation