6O3O

Structure of human DNAM-1 (CD226) bound to nectin-like protein-5 (necl-5)

Summary for 6O3O

Entry DOI	10.2210/pdb6o3o/pdb
Descriptor	CD226 antigen, Poliovirus receptor, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	immune receptor, immunoglobulin domain, adhesion molecule, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	130501.71
Authors	Deuss, F.A.,Watson, G.M.,Rossjohn, J.,Berry, R. (deposition date: 2019-02-27, release date: 2019-07-10, Last modification date: 2023-10-11)
Primary citation	Deuss, F.A.,Watson, G.M.,Goodall, K.J.,Leece, I.,Chatterjee, S.,Fu, Z.,Thaysen-Andersen, M.,Andrews, D.M.,Rossjohn, J.,Berry, R. Structural basis for the recognition of nectin-like protein-5 by the human-activating immune receptor, DNAM-1. J.Biol.Chem., 294:12534-12546, 2019 Cited by PubMed: 31253644 DOI: 10.1074/jbc.RA119.009261 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation