6O3C
Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8
Summary for 6O3C
Entry DOI | 10.2210/pdb6o3c/pdb |
Descriptor | Smoothened homolog, NbSmo8, PHOSPHATE ION, ... (9 entities in total) |
Functional Keywords | gpcr, signaling, hedgehog, smoothened, cholesterol, sag, signaling protein |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 77051.01 |
Authors | Deshpande, I.S.,Liang, J.,Hedeen, D.,Roberts, K.J.,Zhang, Y.,Ha, B.,Latorraca, N.R.,Faust, B.,Dror, R.O.,Beachy, P.A.,Myers, B.R.,Manglik, A. (deposition date: 2019-02-26, release date: 2019-07-03, Last modification date: 2023-10-11) |
Primary citation | Deshpande, I.,Liang, J.,Hedeen, D.,Roberts, K.J.,Zhang, Y.,Ha, B.,Latorraca, N.R.,Faust, B.,Dror, R.O.,Beachy, P.A.,Myers, B.R.,Manglik, A. Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature, 571:284-288, 2019 Cited by PubMed: 31263273DOI: 10.1038/s41586-019-1355-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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