6O0W

Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1 in complex with NADP+ and Bis-Tris

Summary for 6O0W

Entry DOI	10.2210/pdb6o0w/pdb
Descriptor	TIR-NB-LRR type resistance protein RUN1, ADENOSINE-2'-5'-DIPHOSPHATE, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
Functional Keywords	plant disease resistance, signaling protein
Biological source	Vitis rotundifolia (Muscadine grape)
Total number of polymer chains	1
Total formula weight	21349.82
Authors	Horsefield, S.,Burdett, H.,Zhang, X.,Manik, M.K.,Shi, Y.,Chen, J.,Tiancong, Q.,Gilley, J.,Lai, J.,Gu, W.,Rank, M.,Casey, L.,Ericsson, D.J.,Foley, G.,Hughes, R.O.,Bosanac, T.,von Itzstein, M.,Rathjen, J.P.,Nanson, J.D.,Boden, M.,Dry, I.B.,Williams, S.J.,Staskawicz, B.J.,Coleman, M.P.,Ve, T.,Dodds, P.N.,Kobe, B. (deposition date: 2019-02-17, release date: 2019-09-04, Last modification date: 2024-03-13)
Primary citation	Horsefield, S.,Burdett, H.,Zhang, X.,Manik, M.K.,Shi, Y.,Chen, J.,Qi, T.,Gilley, J.,Lai, J.S.,Rank, M.X.,Casey, L.W.,Gu, W.,Ericsson, D.J.,Foley, G.,Hughes, R.O.,Bosanac, T.,von Itzstein, M.,Rathjen, J.P.,Nanson, J.D.,Boden, M.,Dry, I.B.,Williams, S.J.,Staskawicz, B.J.,Coleman, M.P.,Ve, T.,Dodds, P.N.,Kobe, B. NAD+cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365:793-799, 2019 Cited by PubMed: 31439792 DOI: 10.1126/science.aax1911 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation