6O0H

Cryo-EM structure of human ATP-citrate lyase in complex with inhibitor NDI-091143

Summary for 6O0H

• Entry DOI: 10.2210/pdb6o0h/pdb
• EMDB information: 0567 0568
• Descriptor: ATP-citrate synthase, methyl 3-chloro-5-[(4,6-difluoro[1,1'-biphenyl]-3-yl)sulfamoyl]-4-hydroxybenzoate, ADENOSINE-5'-DIPHOSPHATE (3 entities in total)
• Functional Keywords: atp-citrate lyase, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 494672.59

Authors

Wei, J.,Tong, L. (deposition date: 2019-02-16, release date: 2019-04-17, Last modification date: 2024-03-20)

• Primary citation: Wei, J.,Leit, S.,Kuai, J.,Therrien, E.,Rafi, S.,Harwood Jr., H.J.,DeLaBarre, B.,Tong, L.; An allosteric mechanism for potent inhibition of human ATP-citrate lyase.; Nature, 568:566-570, 2019; PubMed: 30944472; DOI: 10.1038/s41586-019-1094-6

Experimental method

ELECTRON MICROSCOPY (3.67 Å)