6NYH
Structure of human RIPK1 kinase domain in complex with GNE684
Summary for 6NYH
Entry DOI | 10.2210/pdb6nyh/pdb |
Descriptor | Receptor-interacting serine/threonine-protein kinase 1, (5S)-N-[(3S)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-pyrido[3,4-b]azepin-3-yl]-5-phenyl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide, IODIDE ION, ... (4 entities in total) |
Functional Keywords | rip1, kinase, rip, rip1k ripk1, immune system, transferase-transferase inhibitor complex |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 68852.08 |
Authors | Fong, R.,Lupardus, P.J. (deposition date: 2019-02-11, release date: 2019-05-29, Last modification date: 2023-10-11) |
Primary citation | Patel, S.,Webster, J.D.,Varfolomeev, E.,Kwon, Y.C.,Cheng, J.H.,Zhang, J.,Dugger, D.L.,Wickliffe, K.E.,Maltzman, A.,Sujatha-Bhaskar, S.,Bir Kohli, P.,Ramaswamy, S.,Deshmukh, G.,Liederer, B.M.,Fong, R.,Hamilton, G.,Lupardus, P.,Caplazi, P.,Lee, W.P.,van Lookeren Campagne, M.,Johnson, A.,McKenzie, B.S.,Junttila, M.R.,Newton, K.,Vucic, D. RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases. Cell Death Differ., 27:161-175, 2020 Cited by PubMed: 31101885DOI: 10.1038/s41418-019-0347-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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