6NXG

Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor 303a

6NXG の概要

• エントリーDOI: 10.2210/pdb6nxg/pdb
• 分子名称: Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, CHLORIDE ION, ... (9 entities in total)
• 機能のキーワード: transferase, structural genomics, seattle structural genomics center for infectious disease, ssgcid, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Plasmodium vivax (strain Salvador I)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 146099.08

構造登録者

Staker, B.L.,Mayclin, S.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2019-02-08, 公開日: 2020-01-01, 最終更新日: 2023-10-11)

• 主引用文献: Harupa, A.,De Las Heras, L.,Colmenarejo, G.,Lyons-Abbott, S.,Reers, A.,Caballero Hernandez, I.,Chung, C.W.,Charter, D.,Myler, P.J.,Fernandez-Menendez, R.M.,Calderon, F.,Palomo, S.,Rodriguez, B.,Berlanga, M.,Herreros-Aviles, E.,Staker, B.L.,Fernandez Alvaro, E.,Kaushansky, A.; Identification of Selective Inhibitors ofPlasmodiumN-Myristoyltransferase by High-Throughput Screening.; J.Med.Chem., 63:591-600, 2020; PubMed: 31850752; DOI: 10.1021/acs.jmedchem.9b01343

実験手法

X-RAY DIFFRACTION (1.6 Å)