6NWS

RORgamma Ligand Binding Domain

Summary for 6NWS

• Entry DOI: 10.2210/pdb6nws/pdb
• Descriptor: Nuclear receptor ROR-gamma, 2-chloro-6-fluoro-N-(1-{[3-(trifluoromethyl)phenyl]sulfonyl}-2,3-dihydro-1H-indol-6-yl)benzamide (3 entities in total)
• Functional Keywords: orphan nuclear receptor, synthetic modulator, chemical probe, nuclear protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 30581.74

Authors

Strutzenberg, T.S.,Park, H.J.,Griffin, P.R. (deposition date: 2019-02-07, release date: 2019-07-10, Last modification date: 2023-10-11)

• Primary citation: Strutzenberg, T.S.,Garcia-Ordonez, R.D.,Novick, S.J.,Park, H.,Chang, M.R.,Doebellin, C.,He, Y.,Patouret, R.,Kamenecka, T.M.,Griffin, P.R.; HDX-MS reveals structural determinants for ROR gamma hyperactivation by synthetic agonists.; Elife, 8:-, 2019; PubMed: 31172947; DOI: 10.7554/eLife.47172

Experimental method

X-RAY DIFFRACTION (2.44 Å)