6NVK
FGFR4 complex with BLU-554, N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide
Summary for 6NVK
Entry DOI | 10.2210/pdb6nvk/pdb |
Descriptor | Fibroblast growth factor receptor 4, SULFATE ION, N-[(3S,4S)-3-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}oxan-4-yl]propanamide, ... (4 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34660.79 |
Authors | Lin, X.,Smaill, J.B.,Squire, C.J.,Yosaatmadja, Y. (deposition date: 2019-02-05, release date: 2019-07-10, Last modification date: 2023-10-11) |
Primary citation | Lin, X.,Yosaatmadja, Y.,Kalyukina, M.,Middleditch, M.J.,Zhang, Z.,Lu, X.,Ding, K.,Patterson, A.V.,Smaill, J.B.,Squire, C.J. Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4. Acs Med.Chem.Lett., 10:1180-1186, 2019 Cited by PubMed: 31413803DOI: 10.1021/acsmedchemlett.9b00196 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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