6NVK

FGFR4 complex with BLU-554, N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide

6NVK の概要

• エントリーDOI: 10.2210/pdb6nvk/pdb
• 分子名称: Fibroblast growth factor receptor 4, SULFATE ION, N-[(3S,4S)-3-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}oxan-4-yl]propanamide, ... (4 entities in total)
• 機能のキーワード: transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34660.79

構造登録者

Lin, X.,Smaill, J.B.,Squire, C.J.,Yosaatmadja, Y. (登録日: 2019-02-05, 公開日: 2019-07-10, 最終更新日: 2023-10-11)

• 主引用文献: Lin, X.,Yosaatmadja, Y.,Kalyukina, M.,Middleditch, M.J.,Zhang, Z.,Lu, X.,Ding, K.,Patterson, A.V.,Smaill, J.B.,Squire, C.J.; Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4.; Acs Med.Chem.Lett., 10:1180-1186, 2019; PubMed: 31413803; DOI: 10.1021/acsmedchemlett.9b00196

実験手法

X-RAY DIFFRACTION (2.3 Å)