6NUJ

HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor BI-224436

6NUJ の概要

• エントリーDOI: 10.2210/pdb6nuj/pdb
• 分子名称: Integrase, (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid (3 entities in total)
• 機能のキーワード: hiv, integrase, inhibitor, allosteric, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18886.19

構造登録者

Lindenberger, J.J.,Kvaratskhelia, M. (登録日: 2019-02-01, 公開日: 2019-12-11, 最終更新日: 2023-10-11)

• 主引用文献: Koneru, P.C.,Francis, A.C.,Deng, N.,Rebensburg, S.V.,Hoyte, A.C.,Lindenberger, J.,Adu-Ampratwum, D.,Larue, R.C.,Wempe, M.F.,Engelman, A.N.,Lyumkis, D.,Fuchs, J.R.,Levy, R.M.,Melikyan, G.B.,Kvaratskhelia, M.; HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.; Elife, 8:-, 2019; PubMed: 31120420; DOI: 10.7554/eLife.46344

実験手法

X-RAY DIFFRACTION (2.10002700303 Å)