6NU1
Crystal Structure of Human PKM2 in Complex with L-cysteine
Summary for 6NU1
Entry DOI | 10.2210/pdb6nu1/pdb |
Descriptor | Pyruvate kinase PKM, CYSTEINE, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (7 entities in total) |
Functional Keywords | pyruvate kinase m2, cysteine, inhibition, glycolysis, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 243125.59 |
Authors | Srivastava, D.,Nandi, S.,Dey, M. (deposition date: 2019-01-30, release date: 2019-08-21, Last modification date: 2023-10-11) |
Primary citation | Srivastava, D.,Nandi, S.,Dey, M. Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2. Biochemistry, 58:3669-3682, 2019 Cited by PubMed: 31386812DOI: 10.1021/acs.biochem.9b00349 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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