6NTS

Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP)

6NTS の概要

• エントリーDOI: 10.2210/pdb6nts/pdb
• EMDBエントリー: 0510
• 分子名称: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... (5 entities in total)
• 機能のキーワード: holoenzyme complex, phosphatase, activator, hydrolase-activator complex, hydrolase/activator
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 157296.80

構造登録者

Huang, W.,Taylor, D. (登録日: 2019-01-30, 公開日: 2020-05-06, 最終更新日: 2023-11-15)

• 主引用文献: Leonard, D.,Huang, W.,Izadmehr, S.,O'Connor, C.M.,Wiredja, D.D.,Wang, Z.,Zaware, N.,Chen, Y.,Schlatzer, D.M.,Kiselar, J.,Vasireddi, N.,Schuchner, S.,Perl, A.L.,Galsky, M.D.,Xu, W.,Brautigan, D.L.,Ogris, E.,Taylor, D.J.,Narla, G.; Selective PP2A Enhancement through Biased Heterotrimer Stabilization.; Cell, 181:688-701.e16, 2020; PubMed: 32315618; DOI: 10.1016/j.cell.2020.03.038

実験手法

ELECTRON MICROSCOPY (3.63 Å)