6NTJ

Neutron/X-ray crystal structure of AAC-VIa bound to gentamicin C1A

6NTJ の概要

• エントリーDOI: 10.2210/pdb6ntj/pdb
• 分子名称: Aminoglycoside N(3)-acetyltransferase, (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: acetyl transferase, neutron, transferase, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: Enterobacteriaceae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32804.28

構造登録者

Cuneo, M.J.,Kumar, P. (登録日: 2019-01-29, 公開日: 2019-09-25, 最終更新日: 2024-04-03)

• 主引用文献: Kumar, P.,Agarwal, P.K.,Waddell, M.B.,Mittag, T.,Serpersu, E.H.,Cuneo, M.J.; Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad.; Angew.Chem.Int.Ed.Engl., 58:16260-16266, 2019; PubMed: 31515870; DOI: 10.1002/anie.201908535

実験手法

NEUTRON DIFFRACTION (2.35 Å)
X-RAY DIFFRACTION (1.9 Å)