6NR0

SIRT2(56-356) with covalent intermediate between mechanism-based inhibitor Glucose-TM-1beta and 1'-SH ADP-ribose

6NR0 の概要

• エントリーDOI: 10.2210/pdb6nr0/pdb
• 分子名称: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, N~2~-[3-(2-hydroxyethoxy)propanoyl]-N-phenyl-N~6~-tetradecanethioyl-L-lysinamide, ... (8 entities in total)
• 機能のキーワード: inhibitor, intermediate, deacylase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75381.14

構造登録者

Price, I.R.,Hong, J. (登録日: 2019-01-22, 公開日: 2020-01-22, 最終更新日: 2023-10-11)

• 主引用文献: Hong, J.Y.,Price, I.R.,Bai, J.J.,Lin, H.; A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors.; Acs Chem.Biol., 14:1802-1810, 2019; PubMed: 31373792; DOI: 10.1021/acschembio.9b00384

実験手法

X-RAY DIFFRACTION (2.45 Å)