6NPM

Crystal structure of Epstein-Barr Virus Nuclear Antigen-1, EBNA1, bound to fragments

6NPM の概要

• エントリーDOI: 10.2210/pdb6npm/pdb
• 関連するPDBエントリー: 6NPI
• 分子名称: Epstein-Barr nuclear antigen 1, 5-(phenylethynyl)pyridine-3-carboxylic acid (3 entities in total)
• 機能のキーワード: ebna1, dna binding protein, epstein-barr virus, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Epstein-Barr virus (strain B95-8) (HHV-4)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30836.58

構造登録者

Messick, T.E. (登録日: 2019-01-17, 公開日: 2019-03-20, 最終更新日: 2023-10-11)

• 主引用文献: Messick, T.E.,Smith, G.R.,Soldan, S.S.,McDonnell, M.E.,Deakyne, J.S.,Malecka, K.A.,Tolvinski, L.,van den Heuvel, A.P.J.,Gu, B.W.,Cassel, J.A.,Tran, D.H.,Wassermann, B.R.,Zhang, Y.,Velvadapu, V.,Zartler, E.R.,Busson, P.,Reitz, A.B.,Lieberman, P.M.; Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.; Sci Transl Med, 11:-, 2019; PubMed: 30842315; DOI: 10.1126/scitranslmed.aau5612

実験手法

X-RAY DIFFRACTION (1.603 Å)