Summary for 6NPE
| Descriptor | Tyrosine-protein kinase ABL1, SULFATE ION, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ... (6 entities in total) |
|---|---|
| Functional Keywords | activator, kinase, allosteric, signaling protein, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total molecular weight | 71827.43 |
| Authors | |
| Primary citation | Simpson, G.L.,Bertrand, S.M.,Borthwick, J.A.,Campobasso, N.,Chabanet, J.,Chen, S.,Coggins, J.,Cottom, J.,Christensen, S.B.,Dawson, H.C.,Evans, H.L.,Hobbs, A.N.,Hong, X.,Mangatt, B.,Munoz-Muriedas, J.,Oliff, A.,Qin, D.,Scott-Stevens, P.,Ward, P.,Washio, Y.,Yang, J.,Young, R.J. Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies. J. Med. Chem., 62:2154-2171, 2019 PubMed: 30689376 (PDB entries with the same primary citation) DOI: 10.1021/acs.jmedchem.8b01872  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (2.15 Å) |
