6NPE
C-abl Kinase domain with the activator(cmpd6), 2-cyano-N-(4-(3,4-dichlorophenyl)thiazol-2-yl)acetamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase ABL1 | polymer | 298 | 34708.6 | 2 | UniProt (P00519) Pfam (PF07714) In PDB | Homo sapiens (Human) | Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Proto-oncogene c-Abl,p150 |
2 | A, B | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
3 | A, B | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | non-polymer | 493.6 | 2 | Chemie (STI) | |||
4 | A, B | 2-cyano-~{N}-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]ethanamide | non-polymer | 312.2 | 2 | Chemie (KWD) | |||
5 | B | NONAETHYLENE GLYCOL | non-polymer | 414.5 | 1 | Chemie (2PE) | |||
6 | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
A, B: 248 - 531 (UniProt: P00519)
PDB | External Database | Details |
---|---|---|
Met 234 | - | expression tag |
His 235 | - | expression tag |
His 236 | - | expression tag |
His 237 | - | expression tag |
His 238 | - | expression tag |
His 239 | - | expression tag |
His 240 | - | expression tag |
Glu 241 | - | expression tag |
Asn 242 | - | expression tag |
Leu 243 | - | expression tag |
Tyr 244 | - | expression tag |
Phe 245 | - | expression tag |
Gln 246 | - | expression tag |
Gly 247 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 69417.1 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 2410.3 | |
All* | Total formula weight | 71827.4 |