6NNF

Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to VRC01 FR3-03 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.5 Angstrom

Summary for 6NNF

• Entry DOI: 10.2210/pdb6nnf/pdb
• Related: 6NM6
• Descriptor: Envelope glycoprotein gp41, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
• Functional Keywords: hiv-1 envelope prefusion trimer, cd4-binding site antibodies, chimeric antibodies, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 8
• Total formula weight: 187559.51

Authors

Lai, Y.-T.,Kwong, P.D. (deposition date: 2019-01-14, release date: 2019-02-27, Last modification date: 2023-10-11)

• Primary citation: Liu, Q.,Lai, Y.T.,Zhang, P.,Louder, M.K.,Pegu, A.,Rawi, R.,Asokan, M.,Chen, X.,Shen, C.H.,Chuang, G.Y.,Yang, E.S.,Miao, H.,Wang, Y.,Fauci, A.S.,Kwong, P.D.,Mascola, J.R.,Lusso, P.; Improvement of antibody functionality by structure-guided paratope engraftment.; Nat Commun, 10:721-721, 2019; PubMed: 30760721; DOI: 10.1038/s41467-019-08658-4

Experimental method

X-RAY DIFFRACTION (2.762 Å)